Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment.TMZ induces mostly N-alkylation adducts (N7-methylguanine and N3-methyladenine) and some O6-methylguanine (O6mG) adducts.Current models propose that during DNA replication, thymine is incorporated across from O6mG, promoting a futile cyc
This paper provides the design and implementation of an L1-optimal control of a quadrotor unmanned aerial vehicle (UAV).The quadrotor UAV is an underactuated rigid body with four propellers that generate forces along the rotor axes.These four forces are used to achieve asymptotic tracking of four outputs, namely the position of the center of mass o
Abstract Background To describe an ultrastructure in the vitreous base (VB) and its micro-anatomical characteristics by multimodal imaging.Methods Light and transmission electron microscopy of the VB were performed on specimens from post-trauma eyes and one healthy donor eye.Intra-operative fundus images associated with VB abnormalities were captur